In particular, we found that the disruption of conscious access in schizophrenia was associated with cerebral dysconnectivity and abnormal attentional amplification.
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Memory formation requires information processing by the hippocampus, which is influenced by other brain areas sending long-range inputs such as the supramammillary nucleus of the hypothalamus SuM. My results show that the SuM input recruits feedforward inhibition through parvalbumin-expressing basket cells that enhances spike fidelity of CA2 pyramidal neurons, and shapes their bursting activity in conditions of elevated cholinergic tone.
Type-1 cannabinoid receptors CB1R are important modulators of physiological functions. CB1R are expressed in different types of neurons but also in the astrocytes.
However, the physiological roles of astroglial CB1R of the hippocampus in synaptic plasticity and memory remained unknown. Thus, astroglial CB1R contribute to the time and space-specific synaptic actions of astrocytes to promote memory formation. Recently, super-resolution microscopy techniques revealed the molecular clusterization of AMPAR at synapses, opening to a new vision of synaptic transmission properties. During my PhD, I combined super-resolution microscopy and electrophysiology to demonstrate that AMPAR nanodomain misalignment regarding glutamate release site strongly impairs synaptic transmission efficiency.
Laboratory research is complemented with both core and track-specific courses, as well as advanced courses on current topics in neuroscience. These are taught in a tutorial format with small groups of faculty and students discussing cutting-edge research in areas such as neural development, neural aging, neurogenetics, addiction and electrophysiology.
The Neuroscience Track is very unique in that the student body is currently divided between Florida and Minnesota, which highlights the uniqueness of Mayo Clinic in that research is present across different campuses. And faculty members are all very approachable and supportive. They give a lot of feedback to students during journal clubs and works-in-progress seminars.
Neuroscience is a burgeoning field that not all institutions have the resources to pursue. The Neuroscience Track has graduated more than students, all of whom have gone on to successful careers in diverse areas such as academia, the pharmaceutical industry, scientific publishing and intellectual property.
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Our students and faculty publish at the highest levels and our scientific endeavors have made — and continue to make — a very real impact at the bench and in the clinic. Welcome to neuroscience at Mayo Clinic, where we offer training for graduate students in a broad range of basic science, translational, and clinical laboratories conducting cutting-edge research with a focus on translating research findings into treatments for disorders of the nervous system.
The Neuroscience Track delivers a unique, interdisciplinary, educational experience with vibrant student populations at Mayo Clinic's campuses in both Rochester, Minnesota, and Jacksonville, Florida.
PIN Program Requirements for Current Students
Pamela McLean, Ph. College of Medicine and Science. Academics Section Overview Academic programs. Admissions and Tuition Section Overview Residencies and fellowships.
About Section Overview College profile. Patient Care College Research. Search Search Mayo Clinic Search. Neuroscience Track. Guaranteed 5-year internal fellowship includes full tuition, stipend and benefits.
Committee members must also be willing to read and evaluate the thesis. The committee should serve the needs of the student. The student is responsible for organizing an initial meeting of the committee, ideally within one month of formation of this committee, but in any event no later than April 30 of the 3rd year.
Subsequent meetings of the committee must occur at a minimum of once every 12 months. Meetings with the Chair must occur every 6 months. Students must meet with their thesis committees each year as follows:. The program will not process paperwork for enrollment and stipend support for students who have not done so unless the program director has approved an exception. The student is responsible for organizing all of these meetings.
If student fails to meet this responsibility, the program will intervene.
Either the student or committee may initiate more frequent meetings as needed. Meetings may be held when necessary without all committee members. The outside member is not expected to attend these meetings. For each meeting, the student is responsible for preparing a written summary outlining the thesis project, progress on this project and objectives for completion of the thesis. This should include a time table.
Preparation of Thesis - Neuroscience - Western University
The summary should make clear what would be necessary to constitute an acceptable Ph. A copy of this summary is to be given to each member of the thesis committee and to the Neuroscience Program Office. Students should present and discuss critically experiments successful or unsuccessful at each meeting.